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Structural biology

Structural Biology :

As per the available reports 5 conferences, 73 Conference Proceedings, 21 National symposiums are especially dedicated to structural biology and 2 Open Access Articles have been published.

Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function.

Structural biology can help us to see some of the detail missing from this view and consequently is a powerful tool to unpick the intricate and exquisite choreography of life. For centuries, we have been able to visualise structures inside a cell, but even the most powerful microscopes are limited in the detail they provide, either by the sheer physical boundaries of magnification, or because the samples themselves are not alive and working. Structural biology methods delve beneath these limits bringing molecules to life in 3D and into sharper focus. It reaches to the very limits of how a molecule works and how its function can be modified. The process of determining molecular structure can be long and frustrating – sometimes taking years. Mostly, proteins are the targets for structure analysis as these are the main ‘doing’ molecules of the cell.
Proteins are built from a DNA template and the string of amino acids thus synthesized fold into very complex loops, sheets and coils – it might seem like a tangle, but this structure dictates how the protein will interact with other structures around it in order to undertake its duties in the cell. The elegant structures of molecules and the complexes they form can be breathtaking in their logic and symmetry, but they are also supreme in helping us to understand how cells actually work. Suddenly shapes, sizes and assemblies of molecules can be assigned to various compartments in cells and put into context with their surrounding environment. A key aim of structural cell biology is to build a landscape representation of cellular function. The emergent picture will be akin to a sophisticated and dynamic metropolis where molecular relationships are forged and broken, short- or long-lived and all are shaped by the inevitability of cell reproduction, aging and death. To discover the 3D structure of a protein, the most common route is to crystallise it.

This stabilises many identical protein molecules in a crystal lattice which, when bombarded with X-rays, provides diffraction data giving valuable information on the spatial relationships of atoms in the protein. From these data, the 3D structure can be built, from scratch if necessary, but more commonly in today’s structural biology laboratories, by comparison with other similar structures. The resulting image of a protein structure can depict its size, how it is folded up, what the overall ‘shape’ is and where any special ‘decorations’ are attached. These images are, of course, artificial; a protein doesn’t actually look like the images generated, the reality of protein structure in nature being dynamic and therefore more indistinct. Some proteins are hard or impossible to crystallise in which case other techniques can be used to determine the structure.
These other methods such as nuclear magnetic resonance, microscopy, electron tomography or mass spectroscopy give different views of proteins at different scales. So to get the richest and most accurate 3D structure of a protein, all of these techniques can be brought together to produce a protein structure that gives more information than just the space it fills. This is correlative structural biology – correlating information from many techniques into one structure that can tell you how the protein works, where it fits inside (or outside) the cell and which other molecules it interacts with. This view of a small part of the cell landscape can be used to identify proteins or even specific parts of proteins that can be targets of designer drugs; perhaps to disable a dysfunctional protein or to modify its behavior.

Structural biology can therefore bring unique information to drug or vaccine discovery programs and be used thereafter to correlate efficacy with the specific changes at an atomic level. It is a key foundation for modern strategies to improve health for the future. Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function. This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and because it is only by coiling into specific three-dimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated way on the molecules' basic composition, or "primary structures. "Hemoglobin, the oxygen transporting protein found in red blood cells. Biomolecules are too small to see in detail even with the most advanced light microscopes. The methods that structural biologists use to determine their structures generally involve measurements on vast numbers of identical molecules at the same time.

Structural biology centers:

In America there are more than 300 structural biology centers and institutes were there, around 11 centers were in Asia, more than 400 centers were there in Europe countries, 100 and more centers in Africa, around 35 centers and institutes were in Australia. OMICS international is organizing more than 8 international conferences in the field of structural biology. OMICS International organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members.

OMICS International Organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members. The conference series website will provide you list and details about the conference organize worldwide.

OMICS Publishing Group, the top runner for its dedicational contribution towards scientific research is conspicuously involved in organizing more than 300 International Conferences across the World and successfully hosts over 400 peer-reviewed open access journals under the fields of science, health, and technology. Also OMICS Group has 21 days rapid review method involving 35,000 editorial team members with 3.5 Million readers. Societies working towards the improvement of science and technology and very actively involved in getting collaborated with more number of associations in upcoming years. The collaborations assist in achieving collective efficiently. OMICS Group Conferences provide a perfect platform for expertise from relevant fields to showcase their contribution towards research.

With the extraordinary success of International conferences in the field of medical, clinical, and life sciences in previous years. Since 2010, OMICS Group International Conferences are included to furnish a momentous stage, for the incredibly famous researchers, scientists, understudies, academicians from organizations, and likewise the business people from businesses Conferences and universal occasions yearly all as far and wide as possible to raise and empower the improvements and concentrate on the exploration viewpoints.

OMICS Group holds the notoriety of adequately arranging investigative gatherings well whatsoever prime areas over the globe. OMICS Group Engineering gatherings are a major hub for researchers; investigate researchers and learners from the field of medical, clinical, engineering, management and life sciences through holding exploratory meetings all as the year progressed. OMICS Group is glad for having the right framework to have such paramount occasions that are lit with members.

Scope and Importance:

The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life.

Tracks:

Cell and Molecular Biology

Systems Toxicology

Recent Advances in Biochemistry

Biochemistry, cell and Molecular Biology

Market Analysis:

Global structural biology and molecular modeling technique market is expected to witness lucrative growth owing to the collaborative efforts focusing on R&D activities and recent advancements in the field of biology. The market is forecasted to witness significant growth as a consequence of novel opportunities in the field of computational biology and sociology in drug discovery processes with computer assisted softwares.

Advances in drug discovery and development process such as the development of innovative computational techniques in modeling biological processes of disease, is expected to serve as a high impact rendering driver for the growth of the industry. These techniques substantially reduce the cost for drug discovery processes, by widening the scope for viable targets and by identifying novel therapeutic strategies for drug development, which is expected to boost the usage rates of these techniques.

Increasing number of computer assisted procedures in structural biology which supports integrative model; serve the market with significant growth opportunities during the forecast period.

Emerging trends in developing sophisticated softwares that serve as integrated environment with latest modules for performing all modeling operations in molecular biology and chemistry are expected to facilitate the market growth.

Asia pacific is expected to be one of the fastest growing regional segments owing to the rapidly improving infrastructure pertaining to research and development in pharmaceutical industry. In addition, favorable government initiatives triggering the need for research activities with novel drug developments to effectively curb with the increasing prevalence of various diseases such as diabetes, cancer and HIV, are expected to drive the market growth.

List of conferences on structural biology:


    List of Associations on Structural Biology:

  • American Societies for Experimental Biology
  • American Society For Cell Biology
  • Asian Regional Conference on Systems Biology
  • Kim Group : Structural Biology Lab
  • Association of Applied Biologists
  • Indian Society of Cell Biology
  • New England Structural Biology Association
  • Ceske Budejovice Czech Crystallographic Association
  • American Crystallographic Association

 

This page will be updated regularly.

This page was last updated on 11th Sep, 2015

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